HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → tert-Butyl [1-(6-methoxypyridazin-3-yl)piperidin-4-yl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 4-(Boc-amino)-1-(6-chloro-3-pyridazinyl)piperidine | HCID 37967251 | — |
| Solvent | Water | HCID 962 | — |
| Product | tert-Butyl [1-(6-methoxypyridazin-3-yl)piperidin-4-yl]carbamate | HCID 86625870 | 75% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
tert-Butyl [1-(6-chloropyridazin-3-yl)piperidin-4-yl]carbamate (0.50 g, 1.60 mmol) was dissolved in dry MeOH (15 ml) and sodium metal (0.073 g, 3.20 mmol) dissolved in MeOH (5 ml) was added. The reaction mixture was heated at in a microwave reactor at 120° C. for 4 h. The mixture was diluted with water (500 ml) and extracted with EtOAc (200 ml). The organic phase was dried (Na2SO4), filtered and evaporated to yield the title compound (0.37 g, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960380B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-7287a543af424e5b99c45b779645383d |
| Source note | uspto-grants-2011_06 |