HCID 56965700, compound → 3-Azetidinamine, 1-(2-pyridinyl)-

HRID 2422003Notes

Reaction equation

HRID 2422003 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:10][CH:9]([NH:11]C(=O)OC(C)(C)C)[CH2:8]1.ClC1C(N2CC(N)C2)=NC=C(C(F)(F)F)C=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH:9]([NH2:11])[CH2:10]1

Participants

3

Reactant 2

HCID 56965700HCID 56965700, compoundHCID 63761213HCID 63761213, compound

Product 1

HCID 569657023-Azetidinamine, 1-(2-pyridinyl)-

Procedure

The title compound was prepared from tert-butyl (1-pyridin-2-ylazetidin-3-yl)carbamate in a similar manner as described for 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]azetidin-3-amine. 1H NMR (500 MHz CDCl3): δ 1.96 (bs, 2H), 3.59-3.63 (m, 2H), 3.89-3.95 (m, 1H), 4.22-4.27 (m, 2H), 6.26 (d, 1H), 6.55-6.58 (m, 1H), 7.38-7.43 (m, 1H), 8.11 (s, 1H).

Sources & evidence

ORD record
ord-d928672d205c4fe388bd6c4f57b9d6ef
Source dataset
uspto-grants-2011_06
Patent number
US07960380B2

Reaction notes

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