4-Pyridineethanamine → HCID 67241575, compound

HRID 2422129Notes

Reaction equation

Cl[C:2]1[C:3](=[O:18])[N:4]([CH:15]([CH3:17])[CH3:16])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][NH2:27])=[CH:21][CH:20]=1>>[CH:15]([N:4]1[C:3](=[O:18])[C:2]([NH:27][CH2:26][CH2:25][C:22]2[CH:23]=[CH:24][N:19]=[CH:20][CH:21]=2)=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:5]1(=[O:14])=[O:13])([CH3:17])[CH3:16]

Participants

Reactant 2

HCID 832754-Pyridineethanamine

HCID 672431604-Chloro-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 67241575HCID 67241575, compound

Procedure

The title compound was prepared from 4-chloro-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and (2-pyridin-4-ylethyl)amine in a similar manner as described for Example 118. 1H NMR (500 MHz CDCl3): δ 1.59 (d, 6H), 2.58 (t, 2H), 3.18 (q, 2H), 4.37-4.45 (m, 1H), 5.44 (t, 1H), 6.71-6.73 (m, 2H), 7.46-7.57 (m, 5H), 8.44-8.46 (m, 2H); 13C NMR (125 MHz CDCl3): δ 20.37, 35.42, 44.14, 47.90, 107.90, 123.96, 125.15, 129.14, 130.19, 131.83, 135.12, 146.48, 150.27, 158.57; Mass Spectrum: M+H+ 372.

Sources & evidence

ORD record: ord-918babbc0b1e4ad083622096324f420e
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07960380B2

Reaction notes

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