2-(3,5-Dimethyl-1H-pyrazol-4-yl)-ethylamine dihydrochloride → HCID 67243315, compound

HRID 2422132Notes

Reaction equation

HRID 2422132 reaction equation
Cl[C:2]1[C:3](=[O:18])[N:4]([CH:15]([CH3:17])[CH3:16])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.Cl.Cl.[CH3:21][C:22]1[C:26]([CH2:27][CH2:28][NH2:29])=[C:25]([CH3:30])[NH:24][N:23]=1>>[CH3:21][C:22]1[C:26]([CH2:27][CH2:28][NH:29][C:2]2[C:3](=[O:18])[N:4]([CH:15]([CH3:17])[CH3:16])[S:5](=[O:14])(=[O:13])[C:6]=2[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:25]([CH3:30])[NH:24][N:23]=1

Participants

3

Reactant 2

HCID 173682302-(3,5-Dimethyl-1H-pyrazol-4-yl)-ethylamine dihydrochlorideHCID 672431604-Chloro-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 67243315HCID 67243315, compound

Procedure

The title compound was prepared from 4-chloro-2-isopropyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and [2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl]amine dihydrochloride in a similar manner as described for Example 24 with TEA as base. 1H NMR (500 MHz, CDCl3): δ 7.53-7.48 (m, 2H), 7.47-7.43 (m, 3H), 5.34 (t, 1H), 4.41 (sept, 1H), 3.01 (q, 2H), 2.41 (t, 2H), 2.05 (s, 6H), 1.58 (d, 6H); 13C NMR (125 MHz CDCl3): δ 158.8, 135.3, 131.5, 129.9, 129.0, 125.3, 111.2, 107.2, 47.8, 43.9, 23.7, 20.4, 10.9; Mass Spectrum: M+H+ 389

Sources & evidence

ORD record
ord-6d29f6cb19e74214bd1c398f709e2726
Source dataset
uspto-grants-2011_06
Patent number
US07960380B2

Reaction notes

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