5-Chloro-2-[(1R)-1-chloroethyl]pyridine → HCID 24762208, compound

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Reaction Steps

The title compound was prepared by general method A starting from (2R)-2-[(2-amino-5-mercapto[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol (823 mg, 2.75 mmol) and 5-chloro-2-[(1R)-1-chloroethyl]pyridine (<4.4 mmol). Purification by flash column chromatography (eluent DCM: methanol gradient) yielded 350 mg (30% yield) of the title compound.

Provenance & Evidence