HCID 58248088, compound → HCID 24821814, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared starting from (2R)-2-[(5-{[1-(3-fluoropyridin-4-yl)ethyl]thio}-2-methoxy[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol from the previous step using General method D, except that the reaction mixture was stirred at 50° C. for 2 h. After complete reaction the reaction mixture was diluted with sat. sodium bicarbonate aq. and water (1:1) and extracted with DCM (three times). The combined organic extracts were dried over sodium sulphate and concentrated in vacuo. The product was purified by flash column chromatography (eluent heptane:ethyl acetate gradient) to yield the title compound as a mixture of diastereomers (194 mg).

Provenance & Evidence