HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylpyridine-4-carbonitrile → 2-((S)-1-Hydroxy-ethyl)-isonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylpyridine-4-carbonitrile | HCID 10464460 | — |
| Reactant | (-)-DIPCl | HCID 86625794 | — |
| Product | 2-((S)-1-Hydroxy-ethyl)-isonicotinonitrile | HCID 59868824 | 78.5% |
Reaction Steps
The title compound (1.13 g, 7.63 mmol) was prepared according to General Method E1 starting from 2-acetyl-isonicotinonitrile (1.42 g, 9.72 mmol) and (−)-DIPCl (4.67 g, 14.57 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960395B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-915dc229d7704dcbb5ce6a0b569369df |
| Source note | uspto-grants-2011_06 |