Hydrochloric Acid → 3-(4-Benzyloxyphenyl)propionic acid

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl 4-(phenylmethoxy)benzenepropanoate (0.60 g, 2.2 mmol) in methanol (20 mL) was added 2N aqueous sodium hydroxide solution (2 mL), and the mixture was stirred at 60° C. for 15 hrs. 2N Hydrochloric acid (3 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with water and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give the title compound (0.38 g, yield 67%).

Provenance & Evidence