Tetrahydrofuran → HCID 67147047, compound

Participants

Reaction Steps

A mixture of methyl (E)-3-[4-[(2,3-dihydro-1H-inden-2-yl)oxy]phenyl]-2-propenoate (0.76 g, 2.6 mmol), tetrahydrofuran (10 mL), methanol (5 mL) and 10% palladium carbon (50% water-containing product, 0.10 g) was stirred overnight at room temperature under a hydrogen atmosphere. The reaction mixture was filtered and concentrated. Water was added, and the mixture was extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated. The residue was recrystallized from ethyl acetate-methanol to give the title compound (0.85 g, yield 89%).

Provenance & Evidence