Hydrochloric Acid → HCID 23136406, compound

Participants

Reaction Steps

To a mixture of methyl (E)-3-[4-[(2,3-dihydro-1H-inden-1-yl) oxy]-3,5-difluorophenyl]-2-propenoate (0.52 g, 1.6 mmol), samarium (1.2 g, 7.9 mmol), tetrahydrofuran (3 mL) and methanol (7 mL) was added iodine (0.80 g, 3.2 mmol), and the mixture was stirred overnight at room temperature. 1N Hydrochloric acid (20 mL) was added and the mixture was stirred for 20 min. The mixture was diluted with water, and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10:1) to give the title compound. yield 60%, oil.

Provenance & Evidence