反应详情

To a solution of 2-chloroacetophenone (4.45 g, 28.8 mmol) and N-propylthiourea (3.40 g, 28.8 mmol) in ethanol (50 mL) was added sodium acetate (3.07 g, 37.4 mmol), and the mixture was heated under reflux for 1.5 hrs. Water was added to the reaction mixture, and crystals were collected by filtration. The obtained crude crystals were recrystallized from diethyl ether-hexane to give the title compound (5.64 g, 92%) as colorless crystals.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1.5 hrs
3. filtrationwere collected by filtration
4. customThe obtained crude crystals
5. customwere recrystallized from diethyl ether-hexane