Sodium sulfate decahydrate → HCID 67146660, compound

Participants

Reaction Steps

Under ice-cooling, to a solution of methyl 4-[[methyl(4-phenyl-1,3-thiazol-2-yl)amino]methyl]benzoate (2.06 g, 6.1 mmol) in tetrahydrofuran (30 mL) was added 0.9 M diisobutylaluminum hydride-hexane solution (30 mL, 27 mmol). The reaction mixture was stirred at room temperature for 2 hrs, sodium sulfate 10 hydrate (8.7 g, 27 mmol) was added and the mixture was stirred at room temperature for 1 hr. Insoluble material was filtered off, and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=1:1) to give the title compound (1.9 g, yield 98%) as a white powder.

Provenance & Evidence