Sodium sulfate decahydrate → (2'-Methyl-6'-propylbiphenyl-3-yl)methanol

Participants

Reaction Conditions

Reaction Steps

To a solution (6.3 mL) of methyl 2′-methyl-6′-propylbiphenyl-3-carboxylate (0.63 g, 2.35 mmol) in tetrahydrofuran was added lithium aluminum hydride (0.089 g, 2.35 mmol) with stirring at 0° C., and the mixture was stirred at the same temperature for 2 hrs. Sodium sulfate 10 hydrate (1.5 g, 4.7 mmol) was gradually added to the reaction mixture, and the mixture was stirred at room temperature for 5 hrs. The insoluble material was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-2/1) to give the title compound (0.50 g, yield 88%) as a colorless oil.

Provenance & Evidence