Triphenylphosphine → HCID 57541958, compound

Participants

Reaction Steps

To a solution of methyl 3-(4-hydroxyphenyl)propanoate (180 mg), 3-(2,6-dimethylbenzyl)benzyl alcohol (226 mg) and triphenylphosphine (286 mg) in toluene (2 mL) was added dropwise diethyl azodicarboxylate (40% toluene solution 500 mg) at room temperature, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was purified by silica gel column chromatography with ethyl acetate-hexane (gradient of 1:9 to 3:2 by volume ratio) to give the title compound (125 mg, yield 32%) as a pale-yellow oil.

Provenance & Evidence