Citric Acid → HCID 57541944, compound

Participants

Reaction Steps

To a solution of methyl 3-(4-{[3-(2-methyl-1-naphthyl)benzyl]oxy}phenyl)propanoate (0.648 g, 1.58 mmol) in a mixture of methanol (6 mL) and tetrahydrofuran (6 mL) was added 2 M aqueous sodium hydroxide solution (2 mL), and the mixture was stirred at room temperature for 75 hrs. Water was added to the reaction mixture, acidified with 10% aqueous citric acid solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give the title compound (0.534 g, yield 85%) as colorless needle crystals.

Provenance & Evidence