HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Cresol → Methyl 3-(4-((3-(2-methylphenoxy)benzyl)oxy)phenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Cresol | HCID 335 | — |
| Reactant | 3-Bromobenzaldehyde | HCID 76583 | — |
| Reactant | Benzenepropanoic acid, 4-hydroxy-, methyl ester | HCID 79706 | — |
| Reactant | [3-(2-Methylphenoxy)phenyl]methanol | HCID 23082899 | — |
| Product | Methyl 3-(4-((3-(2-methylphenoxy)benzyl)oxy)phenyl)propanoate | HCID 23083053 | — |
Reaction Steps
The title compound was synthesized in the same manner as in Example 277 from methyl 3-(4-hydroxyphenyl)propanoate and [3-(2-methylphenoxy)phenyl]methanol (synthesized in the same manner as in Reference Example 201 from o-cresol and 3-bromobenzaldehyde (mixture with side product)) (preparative HPLC (gradient cycle A) was used for purification). colorless oil (yield 28%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960369B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-3476422b94804a7e9a1fd304ed91910e |
| Source note | uspto-grants-2011_06 |