(2,6-Dimethoxyphenyl)boronic acid → Methyl 3-(4-((2',6'-dimethoxybiphenyl-3-yl)methoxy)phenyl)propanoate

HRID 2422302Notes

Reaction equation

HRID 2422302 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:9][CH:8]=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[C:25]=1B(O)O>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[C:25]=1[C:2]1[CH:21]=[CH:20][CH:19]=[C:4]([CH2:5][O:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:9][CH:8]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 2734343(2,6-Dimethoxyphenyl)boronic acidHCID 23136270Methyl 4-[(3-bromophenyl)methoxy]benzenepropanoate

Product 1

HCID 23083169Methyl 3-(4-((2',6'-dimethoxybiphenyl-3-yl)methoxy)phenyl)propanoate

Procedure

The title compound was synthesized in the same manner as in Example 22 from methyl 3-[4-[(3-bromobenzyl)oxy]phenyl]propanoate and 2,6-dimethoxyphenylboronic acid. colorless oil (yield 93%).

Sources & evidence

ORD record
ord-be01ecdbd41d4c7ca27029eaa81b9a40
Source dataset
uspto-grants-2011_06
Patent number
US07960369B2

Reaction notes

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