HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide diethylacetal → 3-(Dimethylamino)-2-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide diethylacetal | HCID 70913 | — |
| Reactant | 5-(Trifluoromethyl)-1,3,4-thiadiazol-2-ylacetic acid ethyl ester | HCID 68755079 | — |
| Product | 3-(Dimethylamino)-2-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acrylic acid methyl ester | HCID 67456509 | — |
Reaction Steps
3.05 g (13.5 mmol) 5-(trifluoromethyl)-1,3,4-thiadiazol-2-ylacetic acid ethyl ester [for preparation see DE 42 40 168-A1] are heated in 6.9 ml (40.5 mmol) dimethylformamide diethyl acetal overnight at 100° C. After cooling, the mixture is concentrated and the residue is purified by means of preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653111B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-07dd5932190f4f0087ae7f4892ccfbf9 |
| Source note | uspto-grants-2014_02 |