Hydrochloric Acid → HCID 57475115, compound

Participants

Reaction Steps

1,4-Dioxaspiro[4,5]decan-8-one (4.84 g, 31 mmol) followed by potassium cyanide (4.85 g, 74.4 mmol) in water (15 ml) were added with ice cooling to a mixture of 4 N hydrochloric acid (8.1 ml), methanol (4.9 ml) and azetidine (8.5 g, 10 ml, 149 mmol). The mixture was stirred at room temperature for 5 days, then water (50 ml) was added and the mixture was extracted with diethyl ether (3×50 ml). The combined organic phases were dried with sodium sulfate and concentrated to small volume under vacuum. Yield: 6.77 g (98%), oil

Provenance & Evidence