Potassium Carbonate → HCID 22148820, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-6-methoxybenzothiazole (prepared as described by Weinstock et. al., J. Med. Chem. 30: p. 1166 (1987)) and 4-Amino-2,6-dichlorophenol 1.3 g (available from Tokyo Chemical Industry Co., Ltd.) in DMSO (9 mL), was added K2CO3 3.12 g. The mixture was heated at 150° C. for 3 h. The reaction mixture was purified by column chromatography (silica gel, AcOEt:hexane=1:2) to provide the aniline 105 (1.43 g, 56%). mp 158-160° C. 1H NMR (300 MHz/CDCl3) δ 3.84 (3H, s), 3.85 (2H, brs), 6.69 (2H, s) 6.97 (1H, dd, J=2.6 Hz, J=8.9 Hz), 7.18 (1H, d, J=2.6 Hz), 7.61 (1H, d, J=8.9 Hz).

Provenance & Evidence