4-Amino-2-chlorophenol → 2-Chloro-N-(3-chloro-4-hydroxy-phenyl)-4-trifluoromethylbenzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	4-Amino-2-chlorophenol	HCID 77578	—
Reactant	2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride	HCID 2736675	—
Product	2-Chloro-N-(3-chloro-4-hydroxy-phenyl)-4-trifluoromethylbenzenesulfonamide	HCID 18511530	—

Reaction Steps

2-Chloro-N-(3-chloro-4-hydroxy-phenyl)-4-trifluoromethylbenzenesulfonamide was synthesized (92%) from 4-amino-2-chlorophenol (Aldrich) and 2-chloro-4-trifluoromethylbenzenesulfonyl chloride in a similar manner as described in Example 421. 1H NMR (400 MHz, DMSO-d6) δ 10.57 (s, 1H), 10.17 (s, 1H), 8.14 (d, J=1.0 Hz, 1H), 8.12 (d, J=8.3 Hz, 1H), 7.88 (dd, J=8.5, 1.4 Hz, 1H), 7.04 (d, J=2.5 Hz, 1H), 6.88 (dd, J=8.7, 2.5 Hz, 1H), 6.82 (d, J=8.7 Hz, 1H). MS (EI): m/z 384 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07960408B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-234e2aaa3d5e47b59c459a509d1b0270
Source note	uspto-grants-2011_06