HCID 59774917, compound → HCID 25057140, compound

Participants

Reaction Steps

A solution of 4-(3-fluorophenyl)-7-({4-[1-hydroxy-1-(trifluoromethyl)but-3-en-1-yl]-1H-1,2,3-triazol-1-yl}methyl)-2H-chromen-2-one from Step 5 (56 mg, 0.122 mmol) in EtOAc (2 mL) was stirred under H2 (1 atm), in the presence of 10% Pd/C (12 mg), for 17 h. After H2 was evacuated and the system purged with nitrogen, the reaction mixture was filtered through celite. The cake was rinsed with EtOAc and the filtrate concentrated. The residue was subjected to chromatography on silica gel (EtOAc/toluene 25:75) affording the title compound (50 mg). MS (−ESI): 460 (M−H)−.

Provenance & Evidence