Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → HCID 86621973, compound

Participants

Reaction Steps

A solution of (2-hydroxy-4-methylphenyl)(5-methylisoxazol-3-yl)methanone from step 3 (0.93 g, 4.28 mmol) and methyl(triphenylphosphoranylidene)acetate (1.86 g, 5.57 mmol) in toluene (30 mL) was heated to 90° C. for 2 h, concentrated in vacuo, and the residue washed with Et2O and hot acetone to afford the title compound. 1H NMR (400 MHz, acetone-d6): 8.18 (d, 1H), 7.27-7.19 (m, 2H), 6.77 (s, 1H), 6.67 (s, 1H), 2.60 (s, 3H), 2.52 (s, 3H).

Provenance & Evidence