Lithium Hydroxide → HCID 67244290, compound

Participants

Reaction Steps

To a solution of (S)-1-{1-[(4-acetyl-2-cyanoquinolin-7-yl)methyl]-1H-1,2,3-triazol-4-yl}-1-(trifluoromethyl)propyl 4-nitrobenzoate (obtained as described in Example 52, step 4) (47 mg, 0.085 mmol) in THF (2 mL) was added lithium hydroxide 2M (210 uL, 0.42 mmol). The mixture was stirred at room temperature for 2 h. The reaction mixture was then diluted with ethyl acetate, washed with an ammonium chloride sln., brine, dried over MgSO4, filtered and concentrated to yield the title compound. The crude residue was purified by flash chromatography (10% acetone-90% dichloromethane) to give the desired product. 1H NMR (400 MHz, acetone-d6): δ 8.55 (d, 1H), 8.40 (s, 1H), 8.24 (s, 1H), 8.11 (s, 1H), 8.85 (d, 1H), 6.02 (s, 2H), 2.85 (s, 3H), 2.35 (m, 1H), 2.05 (m, 1H), 0.86 (t, 3H).

Provenance & Evidence