HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 7-(Bromomethyl)-2-chloro-4-(4-fluorophenyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-Chloro-4-(4-fluorophenyl)-7-methylquinoline | HCID 86621978 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 7-(Bromomethyl)-2-chloro-4-(4-fluorophenyl)quinoline | HCID 86621979 | — |
Reaction Steps
A solution of 2-chloro-4-(4-fluorophenyl)-7-methylquinoline (2.0 g, 7.4 mmol), N-bromo-succinimide (1.57 g, 8.8 mmol) and AIBN (30 mg, 0.18 mmol) in CCl4 (40 mL) was refluxed for 16 h. The solution was then cooled to rt, filtered and concentrated. Purification on silica gel (eluting with dichloromethane/hexanes, 1:1) gave the title compound. MS (+ESI): 351 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960409B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-9238ea38c98849b290a508295201496e |
| Source note | uspto-grants-2011_06 |