HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 7-(Azidomethyl)-2-chloro-4-(4-fluorophenyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 7-(Bromomethyl)-2-chloro-4-(4-fluorophenyl)quinoline | HCID 86621979 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(Azidomethyl)-2-chloro-4-(4-fluorophenyl)quinoline | HCID 86621980 | — |
Reaction Steps
A solution of 7-(bromomethyl)-2-chloro-4-(4-fluorophenyl)quinoline (1.0 g, 2.9 mmol) and sodium azide (204 mg, 3.1 mmol) in ethanol (40 mL) was refluxed for 16 h. The solution was concentrated and dichloromethane was added. The mixture was filtered, and concentrated to give the title compound. MS (+ESI): 313 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960409B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-98ebb13334d54635b425cccd7baa1047 |
| Source note | uspto-grants-2011_06 |