N-methyl-2-pyrrolidone → HCID 66791009, compound

Participants

Reaction Steps

A solution of 2-(1-{[2-chloro-4-(4-fluorophenyl)quinolin-7-yl]methyl}-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-ol (75 mg, 0.16 mmol) in NMP (0.5 mL) and pyrrolidine (0.5 mL) was stirred at 130° C. in a microwave for 20 min. The reaction was quenched with saturated aqueous NaHCO3 and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduce pressure. Purification on silica gel (eluting with NH4OH/ethanol/dichloromethane, 1:9:90) gave the title compound. MS (+ESI): 501 (M+H)+.

Provenance & Evidence