Hydroxyamine hydrochloride → (2S)-1,1,1-trifluoro-2-[1-[[4-(4-fluorophenyl)-2-[(Z)-N-hydroxy-C-methylcarbonimidoyl]quinolin-7-yl]methyl]triazol-4-yl]butan-2-ol

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Reaction Steps

A solution of (S)-1-[4-(4-fluorophenyl)-7-({4-[1-hydroxy-1-(trifluoromethyl)propyl]-1H-1,2,3-triazol-1-yl}methyl)quinolin-2-yl]ethanone (50 mg, 0.11 mmol) and hydroxylamine hydrochloride (11 mg, 0.16 mmol) in pyridine (1 mL) was stirred at rt overnight. The solution was concentrated and purification on silica gel (eluting with acetone/dichloromethane, 2:8) gave the title compound. MS (+ESI): 488 (M+H)+.

Provenance & Evidence