4-Aminobenzoic Acid → 3-Methyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]pyrido[2,3-d]-pyrimidin-4(3h)-one

Participants

Reaction Steps

Compounds of Examples 16 to 59 can be produced according to the method of Example 15 or a method similar to it or a combination of the method with an ordinary method, but starting from the corresponding aminobenzoic acid, amine and separately prepared aromatic aldehydes such as 4-(3-piperidin-1-ylpropoxy)benzaldehyde, 4-(3-pyrrolidin-1-ylpropoxy)benzaldehyde, 4-[(1-cyclopentyl-4-piperidinyl)oxy]benzaldehyde, 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde, 4-[(1-cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde, 4-[(1-cyclobutylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde, 6-[(1-cyclobutylpiperidin-4-yl)oxy]nicotinaldehyde, 2-[(1-cyclobutylpiperidin-4-yl)oxy]pyrimidine-5-carbaldehyde, 4-{3-[(3S)-3-methylpiperidin-1-yl]propoxy}benzaldehyde.

Provenance & Evidence