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Methylamine → Pyrido[3,4-d]pyrimidin-4(3H)-one, 2-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]-8-methoxy-3-methyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | 3-Amino-2-methoxyisonicotinic acid | HCID 53634618 | — |
| 反応物 | 4-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde | HCID 86624461 | — |
| 生成物 | Pyrido[3,4-d]pyrimidin-4(3H)-one, 2-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]-8-methoxy-3-methyl- | HCID 11539020 | — |
反応手順
The entitled compound was obtained according to the method of Example 15 but starting from 3-amino-2-methoxyisonicotinic acid, methylamine and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde. The obtained compound was recrystallized from ethyl acetate-heptane to give a colorless tabular crystal (m.p. 178.0-180.2° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07960394B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-9038c5b1bc5b425a9dc4565cef3a5663 |
| 出典メモ | uspto-grants-2011_06 |