Dimethylformamide diethylacetal → 3-(Dimethylamino)-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]acrylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[N:8]=[CH:7]1)[CH3:2].C(O[CH:19](OCC)[N:20]([CH3:22])[CH3:21])C>>[CH2:1]([O:3][C:4](=[O:15])[C:5]([N:6]1[CH:10]=[C:9]([C:11]([F:14])([F:12])[F:13])[N:8]=[CH:7]1)=[CH:19][N:20]([CH3:22])[CH3:21])[CH3:2]Participants
3
Procedure
38.0 g (170.8 mmol) of the compound from Example 32A and 58.5 ml (50.3 g, 341.6 mmol) dimethylformamide diethyl acetal are stirred at a bath temperature of 100° C. for 16 h. For working up, the cooled reaction solution is concentrated on a rotary evaporator and the residue is dried in vacuo.
Workup
- customthe cooled reaction solution
- concentrationis concentrated on a rotary evaporator
- customthe residue is dried in vacuo
Sources & evidence
- ORD record
- ord-4e8024f0bb49418f821d91604a6b8723
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08653111B2
Reaction notes
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