Methylamine → 2-{4-[(1-Cyclopentylpiperidin-4-yl)oxy]phenyl}-8-fluoro-3-methylquinazolin-4(3H)-one

HRID 2422613노트

반응식

HRID 2422613 반응식
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][NH2:13].[CH:14]1([N:19]2[CH2:24][CH2:23][CH:22]([O:25][C:26]3[CH:33]=[CH:32][C:29]([CH:30]=O)=[C:28](OC)[CH:27]=3)[CH2:21][CH2:20]2)[CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH:14]1([N:19]2[CH2:24][CH2:23][CH:22]([O:25][C:26]3[CH:33]=[CH:32][C:29]([C:30]4[N:13]([CH3:12])[C:4](=[O:6])[C:3]5[C:2](=[C:10]([F:11])[CH:9]=[CH:8][CH:7]=5)[N:1]=4)=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)[CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

4

반응물 3

HCID 6329MethylamineHCID 5864082-Amino-3-fluorobenzoic acidHCID 860848044-[(1-Cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde

생성물 1

HCID 115969642-{4-[(1-Cyclopentylpiperidin-4-yl)oxy]phenyl}-8-fluoro-3-methylquinazolin-4(3H)-one

실험 절차

The entitled compound was obtained according to the method of Example 15 but starting from 2-amino-3-fluorobenzoic acid, methylamine and 4-[(1-cyclopentylpiperidin-4-yl)oxy]-2-methoxybenzaldehyde.

후처리

  1. customThe entitled compound was obtained

출처 및 근거

ORD 기록
ord-e58551f795a14b1d950bd10c26da6a12
출처 데이터셋
uspto-grants-2011_06
특허 번호
US07960394B2

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