Boron trifluoride → HCID 136343911, compound

Participants

Reaction Steps

7-Bromo-2-[2-methoxy-4-(3-piperidin-1-ylpropoxy)phenyl]-3-methylquinazolin-4(3H)-one (38.5 mg, 0.0792 mmol) was dissolved in CH2Cl2 (0.5 mL), stirred with cooling with ice, and boron trifluoride (1.0 M in CH2Cl2, 160 μL) was added thereto. After stirred for 20 hours at room temperature, the reaction solution was diluted with ethyl acetate, and with cooling with ice, it was poured into aqueous 1 N sodium hydroxide solution, and extracted with ethyl acetate. This was washed with saturated saline water and dried with magnesium sulfate. The organic layer was concentrated under reduced pressure, and purified through silica gel thin-layer chromatography (chloroform/methanol=9/1) to obtain the intended compound (9.5 mg, 25%) as a pale yellow solid.

Provenance & Evidence