2-Fluoroethyl p-Toluenesulfonate → HCID 11605008, compound

HRID 2422631Notes

Reaction equation

HRID 2422631 reaction equation
[Cl:1][C:2]1[N:30]=[CH:29][C:5]2[N:6]=[C:7]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][N:22]4[CH2:26][CH2:25][CH2:24][CH2:23]4)=[CH:14][C:13]=3[O:27][CH3:28])[N:8]([CH3:11])[C:9](=[O:10])[C:4]=2[CH:3]=1.S(C1C=CC(C)=CC=1)(OC[CH2:36][F:37])(=O)=O>>[Cl:1][C:2]1[N:30]=[CH:29][C:5]2[N:6]=[C:7]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][N:22]4[CH2:23][CH2:24][CH2:25][CH2:26]4)=[CH:14][C:13]=3[O:27][CH2:28][CH2:36][F:37])[N:8]([CH3:11])[C:9](=[O:10])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 2560192-Fluoroethyl p-ToluenesulfonateHCID 11502838HCID 11502838, compound

Product 1

HCID 11605008HCID 11605008, compound

Procedure

The intended compound was produced according to the method of Example 60 but starting from 6-chloro-2-[2-methoxy-4-(3-pyrrolidin-1-ylpropoxy)phenyl]-3-methylpyrido[3,4-d]pyrimidin-4(3H)-one and 2-fluoroethyl tosylate.

Workup

  1. customThe intended compound was produced

Sources & evidence

ORD record
ord-6cf00c6f263040a88b07645e154b55dc
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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