HCID 11596764, compound → HCID 11603286, compound

Participants

Reaction Steps

6-Chloro-3-methyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]pyrido[3,4-d]pyrimidin-4(3H)-one (42.0 mg, 0.101 mmol) produced in Example 18 was dissolved in ethyl acetate (1 mL), and 10% palladium-carbon (11 mg, 0.0101 mmol) was added thereto and stirred in a hydrogen atmosphere at room temperature for 24 hours. The reaction solution was filtered through Celite, then the Celite was washed with ethyl acetate, and the mother liquid was concentrated. The residue was purified through silica gel column chromatography (chloroform/methanol=3/1) to obtain the intended compound (16.7 mg, 44%) as a colorless solid.

Provenance & Evidence