HCID 67244445, compound → HCID 67246731, compound

Participants

Reaction Steps

3-Methyl-6-nitro-2-[3-(3-piperidin-1-ylpropoxy)phenyl]-4(3H)-quinazolinone (105 mg, 0.248 mmol) was dissolved in methanol (3 mL), and 10% palladium-carbon (26.4 mg, 0.0248 mmol) was added thereto and stirred in a hydrogen atmosphere at room temperature for 4 days. The reaction solution was filtered through Celite, the Celite was washed with ethyl acetate, and the mother liquid was concentrated. The residue was purified through silica gel column chromatography (chloroform/methanol=3/1) to obtain the intended compound (42.8 mg, 44%) as a yellow solid.

Provenance & Evidence