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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2422671Generated: October 25, 2026

Cyclobutanone → 4-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehyde

https://huagongshe.com/reaction/2422671

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclobutanoneHCID 14496—
Reactant(1-Ethoxycyclopropoxy)trimethylsilaneHCID 2734686—
Reactantethyl 4-(1-t-butoxycarbonyl-4-piperidyloxy)benzoateHCID 11783050—
Product4-[(1-Cyclopentyl-4-piperidinyl)oxy]benzaldehydeHCID 86624460—

Reaction Steps

Compounds of Reference Examples 2 and 3 can be produced according to the method of Reference Example 1 but starting from tert-butyl 4-[4-(ethoxycarbonyl)phenoxy]tetrahydro-1(2H)-pyridinecarboxylate and [(1-ethoxycyclopropyl)oxy](trimethyl)silane or cyclobutanone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07960394B2
Source datasetuspto-grants-2011_06
ORD IDord-166efe9e557e43c2be506563d8f5d2c8
Source noteuspto-grants-2011_06