Hydrogen Bromide → 2,5-Dibromo-3-nitropyridine

Participants

Reaction Conditions

Reaction Steps

Hydrogen bromide (48% in H2O, 13 mL) was stirred at 0° C., to which 5-bromo-3-nitropyridin-2-amine (5.0 g, 22.9 mmol) was dropwise added with its inner temperature kept at 5° C. or lower. After the addition, bromine (4.69 mL) and sodium sulfite (6.32 g) were added to it in that order. After stirred at 0° C. for 45 minutes, aqueous sodium hydroxide (9.16 g) solution (10 mL) was added thereto and stirred at room temperature for 1 hour. The resulting solid was taken out through filtration, washed with water and dried to obtain the intended compound (3.80 g, 58.9%).

Provenance & Evidence