HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Amino-5-bromopyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-Amino-5-bromopyridine-2-carboxamide | HCID 21075862 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Amino-5-bromopyridine-2-carboxylic acid | HCID 49761581 | 55% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
3-Amino-5-bromopyridine-2-carboxamide (216 mg, 1.0 mmol) was dissolved in concentrated hydrochloric acid (3 μL), and stirred at 100° C. for 20 hours. After cooled to 0° C., water (10 mL) was added to it and controlled to have a pH of 7 with sodium hydrogencarbonate solution added thereto. The resulting gray solid was taken out through filtration and dried to obtain the intended compound (119 mg, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960394B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-87c61fa41a574b17b8adfc80a75b6d79 |
| Source note | uspto-grants-2011_06 |