Methylamine → HCID 67244656, compound

Participants

Reaction Steps

3-Amino-5-bromopyridine-2-carboxylic acid (500 mg, 2.30 mmol) and N′,N-carbonyldiimidazole (410 mg, 2.53 mmol) were stirred in DMF (5 mL) at 40° C. for 2 hours. After cooled to room temperature, methylamine (2.0 M in THF, 2.3 mL) was added thereto and further stirred at room temperature for 1 hour. The solvent was evaporated off under reduced pressure, and the residue was purified through silica gel column chromatography (chloroform/methanol=9/1 to 4/1) to obtain the intended compound (4.99 g, 94%) as a milky white solid.

Provenance & Evidence