HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 4-(5-Amino-4-methylisothiazol-3-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 3-(4-Methoxyphenyl)-4-methylisothiazol-5-amine | HCID 53401080 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(5-Amino-4-methylisothiazol-3-yl)phenol | HCID 136355285 | 106.8% |
Reaction Steps
Add boron tribromide (0.227 g, 0.909 mmol) to a solution of 3-(4-methoxy-phenyl)-4-methylisothiazol-5-ylamine (0.100 g, 0.455 mmol) in dichloromethane (5 mL) at −20° C. Stir and allow to warm to room temperature. Stir 4 h and quench with 1 N HCl. Extract with EtOAc (2 times 50 mL). Dry (MgSO4) and evaporate. The product is used for the next step without further purification. Yield: 106.8% ES-MS: m/e 207.0 (m+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960419B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-5d928e812cb34a688f8e133b726e02c0 |
| Source note | uspto-grants-2011_06 |