Acetonitrile → 3-Amino-3-(3,4-dichlorophenyl)acrylonitrile

HRID 2422706Notes

Reaction equation

HRID 2422706 reaction equation
CC(C)([O-])C.[K+].[C:7](#[N:9])[CH3:8].[Cl:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:14]#[N:15]>>[NH2:15][C:14]([C:13]1[CH:16]=[CH:17][C:18]([Cl:19])=[C:11]([Cl:10])[CH:12]=1)=[CH:8][C:7]#[N:9]

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 810513,4-DichlorobenzonitrileHCID 23665647Potassium tert-butoxide

Product 1

HCID 671799923-Amino-3-(3,4-dichlorophenyl)acrylonitrile

Procedure

Using a similar procedure to that of Preparation IX-2, but using 1.5 equivalents of potassium t-butoxide and 1.5 equivalents of acetonitrile per 1 equivalent of 3,4-dichlorobenzonitrile, there is obtained 3-amino-3-(3,4-dichlorophenyl)acrylonitrile.

Workup

  1. customof Preparation IX-2

Sources & evidence

ORD record
ord-918552d9dae24c759e6cd0b30257eb7c
Source dataset
uspto-grants-2011_06
Patent number
US07960419B2

Reaction notes

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