HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2422716Generated: November 1, 2026
4-Fluorophenylboronic acid → (R,R)-N-[4-bromo-3-(4-fluorophenyl)isothiazol-5-yl]-2-methylcyclopropane-carboxamide
https://huagongshe.com/reaction/2422716
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | (R,R)-N-[3,4-dibromoisothiazol-5-yl]-2-methylcyclopropanecarboxamide | HCID 67103560 | — |
| Product | (R,R)-N-[4-bromo-3-(4-fluorophenyl)isothiazol-5-yl]-2-methylcyclopropane-carboxamide | HCID 67180226 | — |
Reaction Steps
Using a similar procedure to that of Preparation VI-3, but using 1.3 equivalents of 4-fluorophenylboronic acid to 1 equivalent of (R,R)—N-[3,4-dibromoisothiazol-5-yl]-2-methylcyclopropanecarboxamide and stirring the reaction mixture at 70° C. for 1 day affords (R,R)—N-[4-bromo-3-(4-fluorophenyl)isothiazol-5-yl]-2-methylcyclopropane-carboxamide. ES-MS: m/e 357.0 (m+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07960419B2 |
|---|
| Source dataset | uspto-grants-2011_06 |
|---|
| ORD ID | ord-bc1cbfc598e64fbbae194e3dc7add928 |
|---|
| Source note | uspto-grants-2011_06 |
|---|
