反应详情

A mixture of 1-[2-(3-methylphenyl)-2H-tetrazol-5-yl]ethanol (93 g, 460 mmol) and Novozyme 435® (10 g) in dry toluene (4800 mL) was stirred slowly. Vinyl acetate (39.2 g, 460 mmol) was added and the mixture was stirred at room temperature for 5 hours. Novozyme 435® was filtrated and washed with toluene (100 mL). The filtrate was concentrated and purified on silica using petroleum ether/ethyl acetate (6:1) as eluent giving the title product (47.92 g, 42%).

1. stirringthe mixture was stirred at room temperature for 5 hours
2. filtrationNovozyme 435® was filtrated
3. washwashed with toluene (100 mL)
4. concentrationThe filtrate was concentrated
5. custompurified on silica