HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2422734Generated: November 1, 2026
Water → (3-Iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester
https://huagongshe.com/reaction/2422734
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl chloroacetate | HCID 66052 | — |
| Reactant | HCID 178506575 | HCID 178506575 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (3-Iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester | HCID 57978086 | — |
Reaction Steps
A mixture of 3-iodo-7-azaindazole (25.50 g) and K2CO3 (41.4 g) in DMF (200 mL) was heated to 85° C. and t-butyl chloroacetate (14.3 mL) was slowly added. The mixture was stirred at this temperature for 1 hour (h), cooled to room temperature followed by the addition of water (300 mL). Filtration of the reaction mixture provided (3-iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07960388B2 |
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| Source dataset | uspto-grants-2011_06 |
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| ORD ID | ord-bdb1ac47fb9446399413235d572ccdc9 |
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| Source note | uspto-grants-2011_06 |
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