1-Indanone, 4-bromo- → 4-(4-Bromo-indan-1-ylmethyl)-1,3-dihydro-imidazole-2-thione

HRID 2422790Notes

Reaction equation

HRID 2422790 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=O.BrC1C=CC=C2C=1C[CH:16]([C:22]1[NH:23][C:24](=[S:27])[NH:25][CH:26]=1)C2>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[CH2:16][C:22]1[NH:23][C:24](=[S:27])[NH:25][CH:26]=1

Participants

3

Reactant 2

HCID 987131-Indanone, 4-bromo-HCID 219861684-(4-Bromo-indan-2-yl)-1,3-dihydroimidazole-2-thione

Product 1

HCID 219860654-(4-Bromo-indan-1-ylmethyl)-1,3-dihydro-imidazole-2-thione

Procedure

Use of 4-bromoindanone (obtained by the procedures in Example NINETEEN-1 (Compound 149) in Method TWENTYFOUR produced 4-(4-bromo-indan-1-ylmethyl)-1,3-dihydro-imidazole-2-thione (Compound 167).

Sources & evidence

ORD record
ord-ab0b6bf990434fb3aad24f629a1aba14
Source dataset
uspto-grants-2011_06
Patent number
US07960423B2

Reaction notes

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