HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 5-hydrazinocarbonylthiophene-2-carboxylic Acid 2-propylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 5-(2-propylcarbamyl)-thiophene-2-carboxylate | HCID 38766575 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-hydrazinocarbonylthiophene-2-carboxylic Acid 2-propylamide | HCID 57688105 | 45% |
Reaction Steps
Methyl 5-(2-propylcarbamoyl)thiophene-2-carboxylate (1.22 g, 5.37 mmol) in ethanol (40 mL) was heated with hydrazine monohydrate (2.7 g) at 85° C. for 16 hours with reflux. After cooling, the solvent was evaporated, the resulting solid was recrystallized from chloroform to give 549.2 mg of the desired product (yield 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07960425B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-bd3f2c7826b4496fab36be605e3918d1 |
| Source note | uspto-grants-2011_06 |