5-Hydrazinocarbonylthiophene-2-carboxylic acid 2-picolylamide → 5-{1-[4-Hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethylidenehydrazinocarbonyl}thiophene-2-carboxylic acid 2-picolylamide

Participants

Reaction Steps

1-[4-Hydroxy-1-methyl-5-(4-trifluoromethylphenyl)-1H-pyrazol-3-yl]ethanone (50 mg, 0.18 mmol) in dimethyl sulfoxide (1.0 mL) was heated with 5-hydrazinocarbonylthiophene-2-carboxylic acid 2-picolylamide (58 mg, 0.21 mmol) prepared in Reference Synthetic Example 2 at 110° C. for 21 hours. The solvent was evaporated, and the residue was washed with water and chloroform to give 79 mg of the desired product (yield 83%).

Provenance & Evidence