4-Fluorobenzenesulfonyl chloride → HCID 24962173, compound

Participants

Reaction Steps

The title compound was synthesized by reacting 2-amino-5-methylbenzoic acid (0.25 g, 1.65 mmol), 4-fluoro-benzenesulfonyl chloride (0.39 g, 1.98 mmol) and sodium carbonate (0.36 g, 3.39 mmol) in 3 mL of water, following the reaction procedure of 10. The white solid obtained after acidification of reaction mixture was filtered, washed with water and dried to give 12 (0.44 g, 85.42%). Crystallization with EtOH gave (0.3 g) white amorphous solid, mp: 159-160° C.; IR (CHCl3) 3177, 1662, 1342, 1148, 667 cm−1; 1H NMR (500 MHz, CDCl3) δ 2.31 (s, 3H, CH3), 7.08-7.86 (m, 7H, aromatic), 9.32 (br, 1H, NH), and 10.18 (s, 1H, COOH). HRMS calcd 332.0363 (C14H12FNO4S.Na+), found 332.0372.

Provenance & Evidence