4-Fluorobenzenesulfonyl chloride → HCID 24961447, compound

Participants

Reaction Steps

The title compound was synthesized by reacting 2-amino-4-methylbenzonitrile (0.25 g, 1.89 mmol) and 4-fluoro-benzenesulphonyl chloride (0.37 g, 1.89 mmol) in 2 mL of dry pyridine, following the reaction procedure of 6.29 The concentrated reaction mixture was poured into ice cold water (300 mL), and resulting pale white solid was filtered, washed with water and dried to gave 13 (0.24 g, 42.8%). Crystallization with EtOH gave (0.15 g) white amorphous solid, mp: 130-132° C.; IR (CHCl3) 3260, 2226, 1376, 1340, 1171, 1156 cm−1; 1H NMR (500 MHz, CDCl3) δ 2.42 (s, 3H, CH3) and 6.90-7.83 (m, 7H, aromatic). HRMS calcd 313.0417 (C14H11FN2O2S.Na+), found 313.0418.

Provenance & Evidence